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. 2020 Jul 2;22(4):90. doi: 10.1208/s12248-020-00471-y

Fig. 1.

Fig. 1

Examples of the stationary point where OFV=0 for the case of two parameter model (i.e., p = 2). Top left: a minimum on the surface, where the curvature is positive in all directions. Top right: a saddle point, marked *, where the curvature is negative in one direction around a point, but positive in the other. Bottom left: a so-called monkey saddle, a degenerate saddle point with reversing curvature (inflection) around a point. Bottom right: a region of non-identifiability, where the curvature is zero in one direction, and all values of θ1 produce the same, lowest OFV value along a vector