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Model F Pharmacokinetic Parameter Values Used for Simulation
| Parameter | Typical value | ω (IIV, variance scale) | Σ (residual error, approx. SD scale) |
|---|---|---|---|
| CL | 2.825120 | 0.211405 | |
| CL – V1 IIV covariance | − 0.01629 | ||
| V1 | 4.189603 | 0.211405 | |
| Q | 15.32572 | ||
| V2 | 9.830136 | ||
| Proportional error | 0.103916 |
IIV, inter-individual variability; SD, standard deviation; CL, clearance; V1, volume of the central compartment; Q, intercompartmental clearance; V2, volume of the peripheral compartment
