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. 2019 Oct 7;21(4):1479–1486. doi: 10.1093/bib/bbz084

Table 1.

Top 10 genes that cause the most gene expression dysregulation in breast cancer

Gene Differentially expressed genes Mutated samples Mutation rate
TP53 13104 333 30.33%
CDH1 9692 133 12.11%
PIK3CA 8612 311 28.32%
GATA3 7949 131 11.93%
MAP3K1 5408 79 7.19%
USH2A 2688 63 5.74%
SPTA1 2656 54 4.92%
TTN 2248 189 17.21%
DMD 1377 53 4.83%
KMT2C 1177 90 8.20%