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Summary of immunocomplexes formed between Actoxumab and TcdA and their fragments as determined by SEC-MALLS
| Antibody | Antigen | Molar ratio (Antibody:antigen) | MW of complex (kDa) | Putative stoichiometry (Antibody:antigen) |
|---|---|---|---|---|
| Actoxumab | – | – | 146 | 1:0 |
| Fab | – | – | 47 | 1:0 |
| – | TcdA | – | 296 | 0:1 |
| – | A1 | – | 100 | 0:1 |
| Actoxumab | TcdA | 1:1 | 2141 | 5:4 |
| 5:1 | 2090 | 5:4 | ||
| Actoxumab | A1 | 1:5 | 359 | 1:2 |
| 1:1 | 394 | 2:1 | ||
| 2:1 | 653 | 3:2 or 4:1 | ||
| 5:1 | 1453 | 6:5, 7:4, or 8:3 | ||
| Fab | TcdA | 1:5 | 324 | 1:1 |
| 1:1 | 358 | 1:1 or 2:1 | ||
| 5:1 | 389 | 2:1 | ||
| 10:1 | 393 | 2:1 |
