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. 2018 Oct 10;2(4):NS20180005. doi: 10.1042/NS20180005

Figure 2. Physiological functions of Rab proteins phosphorylated by LRRK2.

Figure 2

(A) Rab29/7L1 acts upstream of LRRK2, leading to its activation. Other Rab proteins are then endogenously phosphorylated by LRRK2. Rab3A/B/C/D are predominantly expressed in the brain and are involved in synaptic vesicle release. Rab8A/B and Rab10 are involved in endolysosomal trafficking. Rab8A/B and Rab10 have been shown to regulate primary ciliogenesis. Increased levels of Rab35 were detected in serum samples of PD patients compared with healthy controls, suggesting that Rab35 is involved in the pathogenesis of PD. (B) Phosphorylated Rab8A/B, Rab10, and Rab12 interact with RILPL1, whereas phosphorylated Rab8A and Rab10, but not Rab12, interact with RILPL2. It has also been shown that phosphorylated Rab8A binds to EHBP1L1.