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. 2020 Jul 21;16(7):e1008599. doi: 10.1371/journal.ppat.1008599

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© 2020 Silva et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 2 — (A) HO-1 promotes increased resistance in acute T. cruzi infection in mice. HO-1 expression reduces macrophage and heart parasitism and is associated with increased resistance to the infection during acute and chronic phases of the disease. (B) Up-regulation of HO-1 expression in macrophages reduces intracellular ROS and labile iron pool through FtH and ferroportin-1 expression. The net result is reduction of parasitism. FtH, ferritin H chain; HO-1, heme oxygenase 1; IFN, interferon; NRF2, nuclear factor erythroid 2-related factor 2; ROS, reactive oxygen species; Teff, T effector cells; TNF, tumor necrosis factor; Treg, regulatory T cell.