Table 2. Association between SHISA3 hypermethylation and clinicopathological parameters of breast cancer patients.
| Parameters | Number (n = 103) | SHISA3 promoter methylation status | P value | |
|---|---|---|---|---|
| Methylated n (%) | Un-methylated n (%) | |||
| Age (Years) | 0.713 | |||
| ≤50 | 35 | 20 (57) | 15 (43) | |
| >50 | 50 | 32 (64) | 18 (36) | |
| Unknown | 18 | 11 (61) | 7 (39) | |
| Histological grade | 0.037 | |||
| Poorly | 32 | 26 (75) | 6 (25) | |
| Well /Moderate | 71 | 37 (52) | 34 (48) | |
| Lymph node metastasis | 0.016 | |||
| Yes | 28 | 23 (82) | 5 (18) | |
| No | 63 | 34 (53) | 29 (47) | |
| Unknown | 12 | 9 (64) | 5 (36) | |
| Clinical stage | 0.664 | |||
| I +II | 44 | 27 (61) | 17 (39) | |
| III+ IV | 59 | 39 (66) | 20 (34) | |
| Tumor size | 0.579 | |||
| ≤5 cm | 44 | 25 (58) | 19 (42) | |
| ≥5cm | 38 | 28 (64) | 10 (36) | |
| Unknown | 21 | 13 (62) | 8 (38) | |