Table 1. Clinical associations of HMGCS1 in a lymph node positive breast cancer patient cohort.

	Grade	ERa	PRb	P53 mutation	HIF1αc
Spearman’s Correlation	0.326	-0.311	-0.393	0.276	0.256
Significance (p-value)	<0.001	<0.001	<0.001	0.001	0.003
n	122	129	124	147	133

Spearman’s correlation coefficients of HMGCS1 to various clinical parameters were determined using a tissue microarray of 149 lymph-node positive breast cancer biopsies as described in Fig 4A. Associations with a p-value of ≤0.05 were considered to be statistically relevant. All statistical analysis was computed in SPSS (IBM, version 20).

^aER, estrogen receptor α

^bPR, progesterone receptor

^cHIF1α, hypoxia inducible factor 1-α