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. Author manuscript; available in PMC: 2020 Jul 21.
Published in final edited form as: Clin Cancer Res. 2019 Jul 12;25(20):6119–6126. doi: 10.1158/1078-0432.CCR-19-0879

Figure 5. Distribution plots for ctDNA clonality and TP53 mutations across SCLC samples.

Figure 5.

Panel A shows distribution of inferred AFs for non-synonymous mutations in different genes across relapse samples, with inferred AF values shown on X-axis. Genes near the top of the Y-axis with higher inferred AF values are likely to represent clonal alterations, while genes below them are more likely to be sub-clonal. Boxes represent interquartile range around the median. Panel B demonstrates pattern of mutations in TP53 that were shed at highest allelic frequency in each individual sample. Tad = Transactivating domain. Tet = Tetrameriization domain.