Table 1.
Comparison of mean arterial contractile responses to increasing concentration of four (S)-epimers of ergot alkaloids, namely ergotaminine, ergocorninine, ergocristinine, and ergocryptinine after normalization to PE at two concentrations where contraction was observed
| Concentration (1 × 10x), M | Contraction, g as % PE contraction, Mean ± SD | Min.1 | Max.2 | |
|---|---|---|---|---|
| Ergotaminine | −7 | 3.90 ± 2.80a | 1.04 | 8.78 |
| −6 | 17.39 ± 4.64c | 10.06 | 22.44 | |
| Ergocorninine | −7 | 1.64 ± 2.21a,b | −0.55 | 5.57 |
| −6 | 10.85 ± 9.35c,d | 0.00 | 27.87 | |
| Ergocristinine | −7 | 2.24 ± 1.94a,b | 0.44 | 5.63 |
| −6 | 7.98 ± 2.71d | 4.01 | 12.13 | |
| Ergocryptinine | −7 | 0.49 ± 0.91b | −0.02 | 2.06 |
| −6 | 7.69 ± 7.10d | −1.71 | 18.62 |
1Minimum arterial contractile response, % contractile response of PE.
2Maximum arterial contractile response, % contractile response of PE.
a–d(S)-epimers demonstrating significant differences between contraction of bovine arteries are designated by different letters at 10−7 M (a,b) and 10−6 M (c,d) (n = 6 arteries/(S)-epimer, total n = 12, GEE, multiple pairwise comparison with Sidak correction, P < 0.05).