Figure 3.
DC vaccination-αCD40 combination therapy improves survival of tumor-bearing mice. (A) Subcutaneous tumor model study setup. Mice were treated with AE17-lysate DCs and FGK45. (B) Tumor volumes measured over time. (C) Tumor size at day 21. (D) Kaplan-Meier analysis of treated and untreated animals. (E) Tumor volumes measured over time. (F) Tumor size at day 22. (G) Kaplan-Meier analysis of treated and untreated animals. (H) Orthotopic tumor model study setup. (I) Percentage of tumor bearing mice. (J) Tumor weight on day 17. n=8–10 per group. Significance was determined using the non-parametric Mann-Whitney U test or log-rank test. Data presented as the mean±SEM. *P<0.05, **P<0.01, ***P<0.001. DC, dendritic cell.