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. 2020 Jul 17;13:6967–6974. doi: 10.2147/OTT.S236476

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© 2020 Yu et al.

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MFI2-AS1 promotes thyroid cancer progression via upregulating TRIAP1. (A and B) TRIAP1 was upregulated in thyroid cancer tissues according to TCGA data using GEPIA (Gene Expression Profiling Interactive Analysis) and UALCAN tools for analysis. THCA: Thyroid carcinoma. TCGA: The Cancer Genome Atlas. (C) qRT-PCR analysis showed TRIAP1 was upregulated in thyroid cancer tissues. (D) MFI2-AS1 and TRIAP1 were positively correlated in 43 thyroid cancer tissues. (E and F) CCK8 and colony formation assays were used for analysis of proliferation. NC: negative control. sh: short hairpin RNA. (G) The activity of Caspase-3/7 was detected to determine apoptosis. (H and I) Transwell assay was performed to evaluate cell migration and invasion. *p<0.05.