Table 2.
Meta-analysis of case series studies |
Descriptive data analysis of case reports | |||||
---|---|---|---|---|---|---|
Outcomes | Meta-analysis |
Individual data analysis | ||||
N | I2 | P(%) | 95 %CI | P(%) | ||
Maternal signs and symptoms | ||||||
Fever | 26 | 83.67 % | 0.58 | 0.48 | 0.67 | 0.64 |
Cough | 26 | 85.49 % | 0.52 | 0.42 | 0.62 | 0.60 |
Lymphopenia | 18 | 91.40 % | 0.46 | 0.31 | 0.62 | 0.38 |
Asymptomatic | 20 | 84.94 % | 0.09 | 0.02 | 0.19 | 0.09 |
Dyspnea | 25 | 89.11 % | 0.17 | 0.09 | 0.28 | 0.36 |
Fatigue | 21 | 77.16 % | 0.06 | 0.01 | 0.12 | 0.16 |
Diarrhea | 23 | 48.86 % | 0.03 | 0.01 | 0.06 | 0.04 |
Sore throat | 22 | 66.57 % | 0.03 | 0.01 | 0.08 | 0.22 |
Myalgia | 21 | 83.25 % | 0.06 | 0.01 | 0.14 | 0.24 |
Elevated C-reactive protein | 18 | 89.58 % | 0.48 | 0.34 | 0.63 | 0.55 |
Maternal comorbidities | ||||||
Gestational diabetes | 20 | 39.69 % | 0.04 | 0.02 | 0.07 | 0.21 |
Preeclampsia | 20 | 25.56 % | 0.04 | 0.02 | 0.07 | 0.08 |
Other* | 20 | 63.71 % | 0.13 | 0.08 | 0.2 | 0.44 |
Treatments for COVID-19 infection | ||||||
Antibiotics | 17 | 96.79 % | 0.67 | 0.41 | 0.89 | 0.63 |
Antivirals | 17 | 96.44 % | 0.48 | 0.24 | 0.73 | 0.69 |
Oxygen support | 18 | 90.99 % | 0.31 | 0.19 | 0.46 | 0.71 |
Other included polycystic ovary syndrome, hypothyroidism, hyperthyroidism etc.; P: proportion; CI: confidence interval; I2: measures of heterogeneity across studies; COVID: coronavirus disease.