TABLE 3.
Gene ontology (GO) terms such as biological process, molecular functions, and KEGG pathways of DEGs that are associated with familial hypercholesterolemia from DAVID.
| Category | Term | Count | % | p-value | Fold enrichment | FDR |
| GOTERM_BP_FAT | GO:0030099∼Myeloid cell differentiation | 10 | 4.9 | 4.9E-3 | 3.1 | 8.4E0 |
| GOTERM_BP_FAT | GO:0046907∼Intracellular transport | 24 | 11.8 | 2.3E-2 | 1.6 | 3.4E1 |
| GOTERM_BP_FAT | GO:2001021∼Negative regulation of response to DNA damage stimulus | 4 | 2.0 | 1.3E-2 | 8.1 | 2.1E1 |
| GOTERM_BP_FAT | GO:0018205∼Peptidyl-lysine modification | 10 | 4.9 | 1.4E-2 | 2.6 | 2.2E1 |
| GOTERM_BP_FAT | GO:1901797∼Negative regulation of signal transduction by p53 class mediator | 3 | 1.5 | 2.8E-2 | 11.4 | 4.0E1 |
| GOTERM_BP_FAT | GO:0002755∼MyD88-dependent toll-like receptor signaling pathway | 3 | 1.5 | 3.8E-2 | 9.7 | 5.0E1 |
| GOTERM_MF_FAT | GO:0016209∼Antioxidant activity | 4 | 2.0 | 3.9E-2 | 5.3 | 4.3E1 |
| GOTERM_MF_FAT | GO:0002039∼p53 binding | 5 | 2.5 | 3.4E-3 | 8.0 | 4.8E0 |
| GOTERM_MF_FAT | GO:0046966∼Thyroid hormone receptor binding | 3 | 1.5 | 2.6E-2 | 11.9 | 3.1E1 |
| GOTERM_MF_FAT | GO:0098641∼Cadherin binding involved in cell-cell adhesion | 8 | 3.9 | 1.8E-2 | 3.0 | 2.3E1 |
| GOTERM_MF_FAT | GO:0000989∼Transcription factor activity, transcription factor binding | 14 | 6.9 | 4.1E-3 | 2.5 | 5.7E0 |
| KEGG_PATHWAY | hsa04120:Ubiquitin mediated proteolysis | 6 | 3.0 | 1.3E-2 | 4.2 | 1.4E1 |
| KEGG_PATHWAY | hsa04260:Cardiac muscle contraction | 4 | 2.0 | 4.2E-2 | 5.1 | 3.9E1 |