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. 2020 Jul 15;11:659. doi: 10.3389/fgene.2020.00659

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Copyright © 2020 Wang, Wang, Bhat, Chen, Xu, Mo, Yi and Zhou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Overview of the number of switched isoforms predicted to have functional consequences. (B) Visualization of switched isoform structure. Taking a splicing factor gene, SNRPF, for example, its isoform ENST00000553192.5.1 showed opposite switching pattern compared to others. In addition, three out of five isoforms showed differential isoform expressions, although no difference for the overall gene expression.