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. 2019 Sep 9;150(2):222–230. doi: 10.1093/jn/nxz217

FIGURE 3.

FIGURE 3

Pharmacokinetics of major vitamin E metabolites in rat plasma after supplementation with a single dose of γTmT (28.9 mg γT/kg; 11 mg δT/kg; 5.5 mg α-tocopherol/kg) or δTE/γTE (31.1 mg δTE/kg; 3.9 mg γTE/kg). (A, B, C) The time course of sulfated γ-CEHC, γT-9’S, and γT-11’S in response to the supplementation of γTmT. (D, E, F) The time course of sulfated δ-CEHC, δTE-11’S, and γTE-11’S in response to the supplementation of δTE/γTE. General linear model repeated measure with Bonferroni post hoc test was used for data analyses. Data are expressed as mean ± SEM, n = 3. Labeled means without a common letter differ, P < 0.05. Abbreviations of vitamin E forms and metabolites are shown in Figure 1. CEHC, 2-(β-carboxyethyl)-6-hydroxychroman, also called 3′-COOH; COOH, carboxychromanol; 9′S, sulfated 9′-COOH; 11′S, sulfated 11′-COOH; γT, γ-tocopherol; γTE, γ-tocotrienol; γTmT, γ-tocopherol-rich mixed tocopherol; δT, δ-tocopherol; δTE, δ-tocotrienol; δTE/γTE, δ-tocotrienol-rich tocotrienol.