TABLE 1.
Pharmacokinetic parameters of plasma γT, δT, and their metabolites after 1-time supplement with γTmT (28.9 mg γT/kg; 11 mg δT/kg; 5.5 mg α-tocopherol/kg) in rats1
| AUC, μM × h | Cmax, μM | Tmax, h | T1/2,2 h | |
|---|---|---|---|---|
| γT | 207.5 ± 24.4 | 25.6 ± 5.2 | 4.0 ± 0.0 | 6.4 ± 0.3 |
| δT | 48.9 ± 8.1 | 8.64 ± 0.20 | 2.7 ± 0.7 | 4.3 ± 0.2 |
| γ-CEHC | 2.24 ± 0.02 | 0.14 ± 0.02 | 4.7 ± 1.8 | 30.1 ± 12 |
| SO3-γ-CEHC | 5.47 ± 0.75 | 0.43 ± 0.07 | 7.3 ± 0.7 | 8.2 ± 1.1 |
| SO3-δ-CEHC | 1.99 ± 0.26 | 0.20 ± 0.01 | 6.0 ± 1.2 | 6.9 ± 1.0 |
| γT-9′S | 2.21 ± 0.44 | 0.24 ± 0.04 | 6.0 ± 1.2 | 3.6 ± 0.3 |
| δT-9′S | 0.21 ± 0.02 | 0.036 ± 0.00 | 7.3 ± 0.7 | 1.4 ± 0.0 |
| γT-11′S | 3.52 ± 0.52 | 0.34 ± 0.04 | 6.0 ± 2.0 | 4.6 ± 0.3 |
| δT-11′S | 0.23 ± 0.03 | 0.036 ± 0.01 | 4.7 ± 0.7 | 4.0 ± 2.6 |
| γT-13′S | 1.02 ± 0.24 | 0.26 ± 0.07 | 4.0 ± 0.0 | 6.1 ± 2.1 |
| δT-13′S | 0.24 ± 0.04 | 0.10 ± 0.01 | 4.7 ± 0.7 | 3.3 ± 1.1 |
| γT-13′ | 0.032 ± 0.021 | 0.010 ± 0.01 | 4.7 ± 0.7 | 1.9 ± 0.2 |
| δT-13′ | 0.11 ± 0.04 | 0.021 ± 0.0 | 4.0 ± 0.0 | 3.3 ± 0.5 |
| γT-13′-OH | 0.044 ± 0.020 | 0.019 ± 0.0 | 4.0 ± 0.0 | 1.7 ± 0.0 |
| δT-13′-OH | 0.041 ± 0.011 | 0.014 ± 0.0 | 4.0 ± 0.0 | 1.9 ± 0.3 |
1
Values are mean ± SEM, n = 3. Abbreviations of vitamin E forms and metabolites are shown in Figure 1. CEHC, 2-(β-carboxyethyl)-6-hydroxychroman, also called 3′-COOH; Cmax, maximum plasma concentration; COOH, carboxychromanol; Tmax, time at which Cmax was observed; 9′S, sulfated 9′-COOH; 11′S, sulfated 11′-COOH; 13′-OH, 13′-hydroxychromanol; 13′S, sulfated 13′-COOH; γT, γ-tocopherol; δT, δ-tocopherol.
2
Elimination half time (T1/2) is the time taken for the plasma concentration to fall by half after reaching Cmax.