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. 2019 Sep 9;150(2):222–230. doi: 10.1093/jn/nxz217

TABLE 4.

Twenty-four-hour fecal excretion of δTE, γTE, and their metabolites in rats after a single gavage of δTE/γTE in comparison with baseline1

Baseline, nmol δTE/γTE supplement, nmol Total excretion,2 %
γTE 243 ± 74 1110 ± 75* 36.3 ± 0.9
δTE 8.92 ± 1.91 3430 ± 530* 17.4 ± 2.9
γ-CEHC 9.22 ± 1.55 15.9 ± 3.3*
δ-CEHC 1.63 ± 0.22 28.6 ± 6.3*
γTE-7′ 4.92 ± 0.12 15.5 ± 1.3
δTE-7′ n.d.3 9.39 ± 0.97*
γTE-9′ 4.89 ± 0.54 21.3 ± 3.6*
δTE-9′ n.d.3 27.0 ± 3.1*
γTE-11′ 17.7 ± 2.0 65.2 ± 9.8*
δTE-11′ 0.81 ± 0.08 161 ± 16*
γTE-13′ (2DB) 29.4 ± 4.4 116 ± 23*
γTE-13′ (3DB) 6.72 ± 1.52 24.8 ± 4.3*
δTE-13′ (2DB) 1.42 ± 0.21 452 ± 57*
δTE-13′ (3DB) 0.54 ± 0.21 451 ± 67*
γTE-13′OH 6.54 ± 0.89 23.9 ± 3.5*
δTE-13′OH 0.66 ± 0.07 245 ± 28*
γTE-13′S4 1.60 ± 0.32 18.0 ± 3.3*
δTE-13′S4 n.d.3 102 ± 15*
Total δ-metabolites 5.14 ± 0.80 1480 ± 192* 7.49 ± 0.98
Total γ-metabolites 80.9 ± 11.4 301 ± 52* 9.21 ± 1.32
1

Values are mean ± SEM, n = 6. Student's t test was used for comparing δTE/γTE supplement with baseline. *P < 0.05, difference between baseline and δTE/γTE supplement. Abbreviations of vitamin E forms and metabolites are shown in Figure 1. CEHC, 2-(β-carboxyethyl)-6-hydroxychroman, also called 3′-COOH; COOH, carboxychromanol; DB, double bonds on the side chain of carboxychromanol; n.d., nondetectable; 13′-OH, 13′-hydroxychromanol; 13′S, sulfated 13′-COOH; γTE, γ-tocotrienol; δTE, δ-tocotrienol.

2

Total excretion % = (24-h fecal excretion in response to δTE/γTE minus 24-h baseline excretion)/intake.

3

Detection limit: 0.04–0.2 pmol on column.

4

γTE-13′S and δTE-13′S were presented as the sum of 2DB and 3DB.