Table 2.
Multivariate analysis of variables associated with overall survival
| Variable | Univariate analysis |
Multivariate analysis |
||
|---|---|---|---|---|
| Adjusted HR (95% CI) | p-value | Adjusted HR (95% CI) | p-value | |
| Age at metastasectomy | 1.04 (0.99-1.10) | 0.117 | - | - |
| Sex | ||||
| Male | 1 (reference) | - | ||
| Female | 3.29 (1.11-9.71) | 0.031 | - | - |
| Initial stage | 0.569 | |||
| Stage I or II | 1 (reference) | - | ||
| Stage III | 0.64 (0.17-2.39) | 0.504 | - | |
| Stage IV | 0.53 (0.16-1.74) | 0.295 | - | - |
| Type of metastasis | ||||
| Synchronous | 1 (reference) | - | ||
| Metachronous | 1.49 (0.53-4.20) | 0.450 | - | - |
| Primary site | 0.396 | |||
| Rectum | 1 (reference) | - | ||
| Left colon | 0.85 (0.25-2.87) | 0.797 | - | |
| Right colon | 2.06 (0.58-7.33) | 0.263 | - | - |
| Metastatic site | ||||
| Liver | 1 (reference) | - | ||
| Lung or other | 1.45 (0.52-4.04) | 0.473 | - | - |
| Sum of diameter for metastatic lesions at metastasectomy | 1.01 (1.00-1.02) | 0.016 | 1.01 (1.01-1.02) | 0.002 |
| Genomic group | 0.019 | 0.009 | ||
| Group 1 | 1 (reference) | 1 (reference) | ||
| Group 2 | 2.38 (0.60-9.56) | 0.220 | 3.61 (0.81-16.02) | 0.092 |
| Group 3 | 5.16 (1.65-16.14) | 0.005 | 6.98 (2.01-24.20) | 0.002 |
HR, hazard ratio; CI, confidence interval.