Arachidonic acid‐derived 12‐HETE is a highly responsive bioactive lipid signature in White participants after a myocardial infarction (MI) event (24–48 h; mean: 37.73 post‐MI). (A) Distribution of bioactive lipid mediators for arachidonic acid (HETEs: pink‐red), docosahexaenoic acid (HDHAs: light‐dark green), eicosapentaenoic acid (HEPEs: light–dark blue) between Black and White subjects after an MI event within 24–48 h quantified by liquid chromatography–mass spectrometry. (B) Quantified levels in ng/mL of 12‐HETE, 17‐HDHA, and 14‐HDHA in Black and White patients within 24–48 h post‐MI. (C) Representative mass spectrometry spectra displays the peaks of 12‐HETE, 17‐HDHA, and 14‐HDHA in Black (male and female) and White (male and female) participants. HEPE, hydroxyeicosapentaenoic acids; HETE, hydroxyeicosatetraenoic acid; HDHA, hydroxydocosahexaenoic acid. Black, African American; White, European American.