TABLE 2.
Renal endpoints comparison
| Tolvaptan | Furosemide | P value | |
|---|---|---|---|
| Serum creatinine (μmol/L) | |||
| Baseline (n = 18 vs. 15) | 101.7 (77.8, 133.5) | 76.9 (67.2, 107.9) | 0.093 |
| 24‐h change (n = 18 vs. 15) | −7.1 (−12.4, −3.5) | −0.9 (−16.8, 13.3) | 0.416 |
| 48‐h change (n = 16 vs. 15) | −15.9 (−27.4, 7.1) | −1.8 (−5.3, 12.4) | 0.093 |
| 72‐h change (n = 8 vs. 13) | −17.7 (−33.6, 15.9) | 2.7 (0, 19.5) | 0.232 |
| 96‐h change (n = 7 vs. 11) | −15.0 (−32.7, 25.6) | 9.7 (−9.7, 19.5) | 0.205 |
| Blood urea nitrogen (mmol/L) | |||
| Baseline (n = 18 vs. 15) | 9.3 (5.0, 15.0) | 7.9 (7.1, 12.1) | 0.928 |
| 24‐h change (n = 18 vs. 15) | −0.7 (−1.1, 0.4) | −0.4 (−2.5, 0.4) | 0.649 |
| 48‐h change (n = 16 vs. 15) | −1.2 (−3.6, 0.5) | −0.4 (−3.2, 1.1) | 0.513 |
| 72‐h change (n = 8 vs. 13) | −2.1 (−5.4, 2.1) | 0.0 (−1.4, 2.1) | 0.363 |
| 96‐h change (n = 7 vs. 11) | −1.1 (−5.0, 3.2) | −1.1 (−2.5, 3.6) | 0.555 |
| Estimated glomerular filtration rate (mL/min/m2) | |||
| Baseline (n = 18 vs. 15) | 65.8 (36.0, 98.2) | 90.0 (66.0, 107.0) | 0.143 |
| 24‐h change (n = 18 vs. 15) | 5.75 (2.00, 8.00) | 0.80 (−11.20, 13.00) | 0.187 |
| 48‐h change (n = 16 vs. 15) | 10.50 (−7.15, 13.00) | 1.00 (−9.00, 4.00) | 0.105 |
| 72‐h change (n = 8 vs. 13) | 9.00 (−17.80, 18.00) | −1.00 (−16.00, 0.00) | 0.310 |
| 96‐h change (n = 7 vs. 11) | 7.00 (−8.00, 15.00) | −3.00 (−19.00, 10.00) | 0.173 |
Median (IQR: 25% and 75% quantile).