TABLE 3.

Biomarker comparisons

	Tolvaptan	Furosemide	P value
NT‐proBNP (ng/L)
Baseline (n = 18 vs. 15)	5,190 (3,834, 9,917)	8,080 (4,488, 12,645)	0.143
% change 0–24 h (n = 18 vs. 15)	2.28 (−17.74, 14.91)	−15.25 (−53.52, 9.56)	0.187
% change 0–96 h (n = 7 vs. 11)	15.97 (−45.86, 39.50)	−26.32 (−80.52, 1.12)	0.469
Cystatin C (mg/L)
Baseline (n = 18 vs. 15)	1.16 (0.91, 1.37)	1.03 (0.95, 1.32)	0.691
% change 0–24 h (n = 18 vs. 15)	−8.56 (−13.68, −5.51)	3.57 (−6.19, 10.99)	0.038
% change 0–96 h (n = 7 vs. 10)	2.38 (−14.13, 17.91)	1.77 (−7.07, 9.94)	1.000
Plasma renin activity (ng/mL)
Baseline (n = 18 vs. 15)	15.25 (1.00, 32.33)	16.88 (6.06, 39.12)	0.986
% change 0–24 h (n = 18 vs. 15)	−23.31 (−34.79, 29.23)	−16.31 (−40.75, 71.43)	0.396
% change 0–96 h (n = 7 vs. 10)	−49.22 (−62.96, 12.66)	1.68 (−39.60, 152.38)	0.354
Copeptin A (ng/mL)
Baseline (n = 17 vs. 15)	56.50 (19.40, 65.00)	25.40 (17.30, 54.70)	0.162
% change 0–24 h (n = 17 vs. 15)	29.30 (−14.96, 55.68)	−9.33 (−24.06, −0.65)	0.059
% change 0–96 h (n = 6 vs. 11)	35.58 (11.45, 90.15)	−14.32 (−39.31, 4.13)	0.119
Urinary NGAL:Cr (ng/mL/g)
Baseline (n = 18 vs. 15)	28.31 (16.58, 135.56)	40.26 (32.29, 73.68)	0.600
% change 0–24 h (n = 17 vs. 15)	−20.50 (−40.52, −3.74)	−10.49 (−45.12, 50.34)	0.910
% change 0–48 h (n = 17 vs. 14)	−7.42 (−36.65, 73.95)	−14.20 (−48.34, 51.89)	0.463
% change 0–72 h (n = 8 vs. 13)	49.37 (−7.24, 123.81)	−24.94 (−35.56, 34.22)	0.089

Median (IQR: 25% and 75% quantile).