FIGURE 3.
The editing pathways. Schematic overview of the editing pathways used by the synthetases. In the figure above, the events are in italics, while the editing paths are in bold. The pathways are divided between pretransfer and posttransfer pathways. In the pretransfer editing, the activated noncognate aminoacyl-adenylate may be released from the enzyme and hydrolyze spontaneously or be edited within the active site or a specialized active site. Upon transfer to the tRNA, the aminoacyl-tRNA can be translocated to the editing site or released and cleared by a dedicated trans-editing factor. The cognate aminoacyl-tRNA binds the elongation factors and proceeds to translation in the ribosome.