Table 4.

The effect of the individual and community benefits of PrEP on inside and outside incidence for the case of a PrEP program for MSM in India.

	Individual Benefit of PrEP (direct benefit)	Additional Community Benefit of PrEP (indirect benefit)
Inside Incidence	For PrEP uptakers, inside incidence drops immediately according to efficacy and adherence. Those who do not take PrEP do not receive any direct benefit.	For both PrEP uptakers and nonuptakers, due to lower viral load in the primary cohort over time compared to the status quo (fewer number of incident MSM, see Figure 2B), inside transmission, and thus inside incidence, declines gradually. This decline is in addition to the immediate drop for PrEP uptakers.
Outside Incidence	For PrEP uptakers, outside incidence drops immediately according to efficacy and adherence. Those who do not take PrEP do not receive any direct benefit.	For both PrEP uptakers and nonuptakers, we assume outside incidence remains unaffected given that the vast majority of outside incidence is attributable to prevalent MSM and TG (already HIV-infected at model start), for whom viral load is unaffected by PrEP roll out (i.e., arrows 4 and 5 are unaffected by PrEP in Figure 2).

MSM: men who have sex with men; PrEP: pre-exposure prophylaxis; TG: transgender women.