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Lead compounds are not cytotoxic. Brain microvascular endothelial cells (hCMEC/D3 cell line) were treated with each lead compound. LDH, a marker of cell damage was measured at 8 h (A) and 36 h (B) posttreatment. LDH activities were not significantly different from medium/solvent control, suggesting that the lead compounds did not damage the brain endothelial cells.
