Table 2.
Candidate Oncogene Signature for SUM-190 cells.
| Gene symbol | QuantLog | QuantLogRank | Screen hit | Log fold change | DnaAmp | Mutation | Occurences in cosmic | Existing drugs |
|---|---|---|---|---|---|---|---|---|
| PIK3CA | 23.63 | 88 | 1 | PIK3CAp.H1047R | 1889 | ZSTK474, PI-103, A66, BKM120 | ||
| EPHA5 | 8.05 | 787 | 1 | 0 | 1.3009 | 0 | ||
| CRKL | 5.26 | 2135 | 0 | 2.08183288 | 3.3127 | 0 | ||
| CD274 | 4.8 | 2621 | 0 | 0.81917265 | CD274p.R260C | 1 | ||
| ERBB2 | 2.48 | 8269 | 0 | 3.48529258 | 4.4293 | 0 | Lapatinib, CP724714, CUDC-101, Afatinib | |
| CCND1 | 2.4 | 8613 | 0 | 1.84218813 | 1.2862 | 0 | ||
| PAK1 | 2.02 | 10371 | 0 | 1.19466668 | 1.0625 | 0 | IPA-3 | |
| NBN | 1.9 | 11023 | 0 | 0.74382708 | 0.8672 | 0 | ||
| EED | 1.82 | 11397 | 0 | 1.3939 | 0 | |||
| FGF4 | 1.65 | 12158 | 0 | 0.04983281 | 1.2862 | 0 | ||
| FGF3 | 1.6 | 12404 | 0 | 1.2862 | 0 | |||
| CREBBP | 1.36 | 13493 | 0 | 1.33574903 | 0.8509 | 0 | ||
| FGF19 | 1.28 | 13826 | 0 | −0.28420775 | 1.2862 | 0 | ||
| FAM58A | 1.19 | 14135 | 0 | 1.23522966 | 0.9519 | 0 | ||
| BRCA1 | 0.95 | 14857 | 0 | 1.7257694 | 3.0084 | 0 | ||
| RAD51L3 | 0.76 | 15134 | 0 | 0.21738458 | 1.1823 | 0 |