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. 2020 Jul 21;10:12057. doi: 10.1038/s41598-020-68970-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Electron microphotographs of tbl synapses (A–B) in which great endosomes (E) and autophagy vacuoles (a) are easily distinguished. Autophagosomes are most numerous in tbl than in control presynaptic terminals (C, ***p = 8.09153^E−05). No differences stand out in the perimeter length of the presynaptic boutons (D, Perimeter; p = 0.06094) as well as in the perimeter of all membranes measured (D, Total; p = 0.22775) between control and tbl presynaptic boutons; however, the perimeter of the membrane of endosomes and autophagosomes (D, Endosomes) is significantly greater in tbl than in control presynaptic terminals (***p = 5.7819^E−07). The ratios between the active zone and the perimeter length (E, AZ/Perimeter), the values of endodomes and autophagosomes membrane length (E, AZ/Endosomes), and the total length of measured membranes (E, AZ/Total) are consistently greater in control presynaptic terminals than in tbl ones (***p = 2,769^E−06; **p = 0.0017; and, ***p = 1.8152^E−09, respectively). cv, coated vesicles. dcv, dense core vesicles. e, endosomes. m, microtubules; mvb, multivesicular body. sr, smooth endoplasmic reticulum. Bars = 500 nm.