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. 2020 Jul 21;10:12114. doi: 10.1038/s41598-020-69131-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Pattern of pain VAS scores by time in total patients. (pre-treatment, on treatment days 1–5, post-treatment 1-week, 1-month). (B) Pattern of FIQ scores by time in total patients. (C) Pattern of BDI scores by time in total patients. (D) Pattern of BFI scores by time in total patients. Values are shown as the mean ± standard error of the mean. *p < 0.05, **p < 0.01, ***p < 0.001. VAS Visual Analog Scale, FIQ Fibromyalgia Impact Questionnaire, BDI Beck Depression Inventory, BFI Brief Fatigue Inventory.