English speaking publication or English publicly available manuscript (due to accelerated publishing timelines during COVID19, epub manuscripts, available ahead of publication were included as well) |
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Individual data (or mean/SD) of viral RNA load or/and time to clearance of infection is reported |
Needed to provide coherent summary measures |
Clinical severity per subject (if diverse patient population) or whole patient population is reported |
Needed for stratification |
Median age for patient population or per subject is reported |
Needed for stratification |
SARS-CoV-2 detection was performed by RT-PCR with defined thresholds to determine negativity of sample |
Ensures to have identical molecular methodology across studies; needed to determine time to clearance from graph if not reported in text |
Location of sampling is defined and can be categorized into lower tract respiratory (LRT) specimen, upper respiratory tract (URT) and Faeces |
Needed for stratification |
Two consecutive measures were obtained to confirm negativity conversion |
Ensures quality of measures and reduces risk of false negatives |
Time to clearance was either reported from day of symptom onset or day from admission |
Needed to have coherent and clinically meaningful Day 0 set across studies |
Study is a case series, systematic review, prospective observational or retrospective study |
Reduce risk of reporting bias |