Table 1.
Individual results of measuring protein biomarkers in colorectal mucus samples non-invasively collected from CRC patients.
| # | Age (years) | Sex | CRC site | CRC histology | TNM stage | Haemoglobin (ng/ml) |
CRP (ng/ml) |
TIMP1 (ng/ml) |
M2-PK (U/ml) |
MMP9 (ng/ml) |
PADI4 (ng/ml) |
EGFR (pg/ml) |
Calpro (μg/ml) |
EDN (ng/ml) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Proximal tumours | ||||||||||||||
| 1 | 59 | F | Asc | AdCa | SI(T1N0M0) | 0.0 | 0.0 | 1.7 | 2.2 | 18.9 | 1.2 | 511.4 | 1.0 | 3.8 |
| 2 | 74 | M | Asc | AdCa | SI(T2N0M0) | 69.7 | 11.1 | 5.9 | 22.3 | 7.3 | 2.5 | 375.7 | 2.3 | 5.8 |
| 3 | 75 | F | Trans | AdCa | SI(T2N0M0) | 182.6 | 0.0 | 1.0 | 0.8 | 19.8 | 1.3 | 208.8 | 2.1 | 6.6 |
| 4 | 93 | M | Hep fl | AdCa | SIIA(T3N0M0) | 490.3 | 0.0 | 3.6 | 28.0 | 14.8 | 12.3 | 341.7 | 5.1 | 1.5 |
| 5 | 72 | M | Trans | AdCa | SIIA(T3N0M0) | >5000.0 | 535.8 | 12.3 | 19.0 | 54.5 | 1.3 | 583.0 | 9.8 | 19.9 |
| 6a | 23 | F | Caecum | AdCa | SIIA(T3N0M0) | 4855.2 | 96.8 | 8.3 | 12.7 | 40.9 | 1.4 | 471.5 | 15.3 | 39.7 |
| 7 | 71 | M | Trans | AdCa | SIIA(T3N0M0) | 239.6 | 14.6 | 11.0 | 4.9 | 10.7 | 0.5 | 544.4 | 4.3 | 4.9 |
| 8 | 73 | M | Asc | AdCa | SIIIA(T2N1M0) | 991.4 | 17.7 | 7.4 | 22.7 | 44.0 | 2.9 | 547.4 | 14.0 | 4.9 |
| 9 | 90 | F | Trans | Muc Ca | SIIIB(T3N1M0) | 0.0 | 2.5 | 15.5 | 12.8 | 5.2 | 1.4 | 291.2 | 0.4 | 4.6 |
| 10 | 64 | F | Caecum | AdCa | SIIIB(T3N1M0) | 939.3 | 2.7 | 0.8 | 3.0 | 0.4 | 0.2 | 75.8 | 0.6 | 7.1 |
| 11 | 60 | M | Caecum | AdCa | SIIIB(T3N1M0) | 12.2 | 1.1 | 1.0 | 0.5 | 2.7 | 0.0 | 178.4 | 1.7 | 1.3 |
| 12 | 76 | M | Caecum | AdCa | SIIIB(T3N1M0) | 2883.6 | 39.8 | 1.5 | 0.8 | 5.4 | 0.9 | 165.8 | 0.8 | 20.3 |
| 13 | 67 | M | Trans | AdCa | SIIIB(T3N1M0) | 2879.2 | 24.1 | 16.6 | 15.7 | 26.4 | 2.0 | 329.5 | 4.7 | 33.7 |
| 14 | 69 | M | Trans | AdCa | SIIIC(T3N2M0) | 2646.3 | 26.1 | 10.1 | 58.3 | 50.2 | 6.0 | 1456.0 | 21.0 | 25.2 |
| 15 | 52 | M | Caecum | AdCa | SIIIC(T3N2M0) | 0.0 | 28.0 | 0.3 | 3.6 | 3.5 | 0.3 | 41.8 | 0.2 | 1.3 |
| 16 | 60 | M | Trans | AdCa | SIIIC(T3N2M0) | 0.0 | 17.2 | 0.8 | 0.0 | 5.4 | 0.2 | 13.6 | 0.0 | 1.3 |
| 17 | 78 | F | Caecum | AdCa | SIIIC(T3N2M0) | 1896.4 | 15.9 | 8.2 | 11.2 | 41.3 | 5.0 | 103.1 | 3.4 | 9.9 |
| DIstal tumours | ||||||||||||||
| 18 | 64 | M | Rectum | AdCa | SI(T1N0M0) | >5000.0 | 20.9 | 1.5 | 4.4 | 1.9 | 0.3 | 158.8 | 0.6 | 1.9 |
| 19 | 60 | M | Rectum | AdCa | SI(T2N0M0) | >5000.0 | 352.3 | 12.5 | 11.2 | 23.2 | 1.6 | 1076.5 | 17.6 | 39.5 |
| 20 | 64 | M | Sigmoid | AdCa | SI(T2N0M0) | 745.5 | 18.9 | 4.8 | 1.3 | 22.1 | 0.9 | 328.9 | 2.5 | 8.1 |
| 21 | 81 | F | Rectum | AdCa | SIIA(T3N0M0) | >5000.0 | 66.3 | 16.6 | 95.8 | 262.3 | 23.2 | 954.9 | 12.4 | 105.6 |
| 22 | 63 | M | Sigmoid | AdCa | SIIA(T3N0M0) | >5000.0 | 59.0 | >120.0 | 46.0 | 97.3 | 7.4 | 1164.0 | 26.4 | 13.5 |
| 23 | 65 | F | Rectum | AdCa | SIIA(T3N0M0) | 215.5 | 1.3 | 4.7 | 9.9 | 17.3 | 1.3 | 73.1 | 0.3 | 6.9 |
| 24 | 84 | M | Rectum | AdCa | SIIA(T3N0M0) | >5000.0 | 60.4 | 99.7 | 39.3 | 26.4 | 6.7 | 417.5 | 5.2 | 7.8 |
| 25 | 78 | M | Rectum | Muc Ca | SIIA(T3N0M0) | >5000.0 | 40.5 | 0.4 | 2.1 | 1.5 | 0.1 | 80.3 | 2.1 | 3.4 |
| 26 | 60 | M | Sigmoid | AdCa | SIIA(T3N0M0) | >5000.0 | 66.6 | 30.0 | 42.4 | 117.6 | 12.3 | 193.5 | 9.5 | 20.4 |
| 27 | 66 | M | Rectum | AdCa | SIIA(T3N0M0) | 4897.3 | 101.8 | 27.8 | 32.5 | 37.7 | 5.6 | 101.8 | 4.1 | 6.0 |
| 28 | 59 | M | Desc | AdCa | SIIA(T3N0M0) | 124.1 | 285.7 | 37.6 | 28.3 | 52.1 | 3.2 | 285.7 | 9.2 | 24.0 |
| 29 | 70 | M | Sigmoid | AdCa | SIIA(T3N0M0) | 1521.1 | 23.2 | 11.2 | 2.8 | 65.5 | 2.0 | 343.7 | 15.9 | 22.2 |
| 30 | 72 | F | Rectum | Muc Ca | SIIB(T4N0M0) | 295.91 | 11.6 | 2.1 | 9.1 | 6.4 | 0.9 | 1180.5 | 18.4 | 13.3 |
| 31 | 81 | M | Rectum | AdCa | SIIB(T4N0M0) | >5000.0 | 85.7 | 14.7 | 67.5 | 64.8 | 11.1 | 310.5 | 8.4 | 53.5 |
| 32 | 60 | M | Rectum | AdCa | SIIIB(T3N1M0) | >5000.0 | 160.3 | >120.0 | 54.0 | 266.2 | 8.2 | 1069.9 | 22.8 | 32.3 |
| 33 | 69 | F | Rectum | AdCa | SIIIB(T3N1M0) | 40.6 | 7.2 | 0.3 | 3.4 | 9.9 | 0.1 | 8.0 | 0.0 | 1.5 |
| 34 | 55 | F | Sigmoid | AdCa | SIIIB(T3N1M0) | 152.8 | 6.7 | 3.3 | 25.1 | 4.5 | 3.5 | 4771.8 | 3.9 | 28.7 |
| 35 | 71 | F | Sigmoid | AdCa | SIIIC(T3N2M0) | 4.0 | 10.8 | 0.9 | 1.2 | 1.0 | 0.0 | 88.5 | 0.0 | 8.0 |
| 36 | 69 | M | Sigmoid | AdCa | SIIIC(T3N2M0) | >5000.0 | 31.5 | >120.0 | 54.8 | 325.3 | 8.7 | 1242.1 | 22.9 | 23.2 |
| 37 | 60 | M | Sigmoid | AdCa | SIIIC(T3N2M0) | >5000.0 | 64.4 | 68.4 | 12.9 | 134.6 | 1.2 | 464.0 | 144.5 | 17.3 |
| 38 | 36 | F | Sigmoid | Muc Ca | SIIIC(T4N2M0) | 220.0 | 5.8 | 0.6 | 0.0 | 1.8 | 0.2 | 44.5 | 0.0 | 4.4 |
| 39 | 47 | M | Sigmoid | AdCa | SIIIC(T4N2M0) | >5000.0 | 160.4 | >120.0 | 56.5 | 356.9 | 14.3 | 2248.2 | 22.0 | 226.7 |
| 40 | 69 | M | Rectum | AdCa | SIVA(T3N1M1) | 4217.9 | 14.7 | 11.0 | 10.4 | 11.6 | 3.3 | 270.3 | 1.3 | 5.2 |
Results are sorted according to case severity (TNM staging). Biomarker test results shown in bold are positive.
AdCa adenocarcinoma, Asc ascending colon, Desc descending colon, F female, Hep Fl hepatic flexure, M male, Muc Ca mucinous carcinoma, Trans transverse colon.
aLynch syndrome suspected in this case.