. 2020 May 13;123(2):252–260. doi: 10.1038/s41416-020-0893-8

Table 2.

Comparison of tested colorectal mucus biomarker performance for CRC detection vs. groups of asymptomatic healthy volunteers (controls) and patients with abdominal symptoms (based upon ROC curve analysis).

Biomarker	Optimal cut-off level	Sensitivity (%) [95% CI]	AUC vs. control [95% CI]	Specificity vs. control (%) [95% CI]	AUC vs. Sympt. Pat-s [95% CI]	Specificity vs. Sympt. Pat-s (%) [95% CI]	Median biomarker conc. (Control)	Median biomarker conc. (Sympt. Pat-s)	Median biomarker level (CRC)
Haemoglobin	109.3 ng/ml	80.0 [63.4−90.4]	0.921 [0.855−0.986]	94.3 [79.5−99.0]	0.854 [0.773−0.935]	85.5 [73.7−92.7]	0.0 ng/ml^{a, b}	0.0 ng/ml^{a, c}	1708.7 ng/ml^{b, c}
CRP	8.9 ng/ml	72.5 [55.9−84.9]	0.838 [0.747−0.929]	80.0 [62.5−90.9]	0.772 [0.678−0.867]	75.8 [63.0−85.4]	0.0 ng/ml^d	1.4 ng/ml^e	22.1 ng/ml^{d, e}
TIMP1	3.2 ng/ml	67.5 [50.8−80.9]	0.829 [0.736−0.922]	85.7 [69.0−94.6]	0.733 [0.629−0.836]	75.8 [63.0−85.4]	0.7 ng/ml^{f, g}	1.4 ng/ml^f,h	8.3 ng/ml^{g, h}
M2-PK	9.0 U/ml	62.5 [45.8−76.8]	0.835 [0.745−0.925]	94.3 [79.5−99.0]	0.708 [0.604−0.812]	77.4 [64.7−86.7]	0.6 U/ml^{i, j}	3.0 U/ml^i,k	12.0 U/ml^{j, k}
MMP9	10.4 ng/ml	65.0 [48.3−78.9]	0.865 [0.784−0.946]	82.9 [65.7−92.8]	0.698 [0.597−0.799]	64.5 [51.3−76.0]	0.4 ng/ml^{l, m}	6.4 ng/ml^l,n	20.9 ng/ml^{m, n}
PADI4	1.2 ng/ml	67.5 [50.8−80.9]	0.885 [0.811−0.959]	94.3 [79.5−99.0]	0.645 [0.539−0.752]	62.9 [49.7−74.6]	0.0 ng/ml^{o, p}	0.9 ng/ml^o,q	1.5 ng/ml^{p, q}
EGFR	305.5 pg/ml	60.0 [43.4−74.7]	0.803 [0.703−0.903]	88.6 [72.3−96.3]	0.596 [0.483−0.710]	58.1 [44.9−70.3]	67.7 pg/ml^{r, s}	187.0 pg/ml^r	342.7 pg/ml^s
Calprotectin	3.4 µg/ml	57.5 [41.0−72.6]	0.751 [0.641−0.861]	80.0 [62.5−90.9]	0.585 [0.466−0.705]	56.5 [43.3−68.8]	0.6 µg/ml^{t, u}	2.9 µg/ml^t	4.0 µg/ml^u
EDN	12.8 ng/ml	45.0 [29.6−61.3]	0.737 [0.623−0.852]	88.6 [72.3−96.3]	0.521 [0.404−0.639]	62.9 [49.7−74.6]	2.8 ng/ml^{v, w}	10.1 ng/ml^v	8.0 ng/ml^w

P values for CM biomarker level comparisons between study groups:

^aP < 0.01878; ^bP < 0.00001; ^cP < 0.00001; ^dP < 0.00001; ^eP < 0.00001; ^fP = 0.02640; ^gP < 0.00001; ^hP = 0.00008; ⁱP = 0.01352; ^jP < 0.00001; ^kP = 0.00040; ^lP = 0.00288; ^mP < 0.00001; ⁿP = 0.00078; ^oP < 0.00001; ^pP < 0.00001; ^qP = 0.01428; ^rP = 0.00020; ^sP < 0.00001; ^tP = 0.00042; ^uP = 0.00020; ^vP = 0.00064; ^wP = 0.00044.