TABLE 4.
Other Basic TMS Measures
| Mean (SD) | t Testst- Value (p) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Week | 1 | 4 | 12 | 24 | 52 | 1 | 4 | 12 | 24 | 52 |
| IHIrest | IHIR | Patient vs Control | ||||||||
| Patient | 0.69 (0.20) | 0.67 (0.19) | 0.81 (0.16) | 0.79 (0.20) | 0.73 (0.25) | 0.81 (0.44) | 0.60 (0.56) | 0.11 (0.56) | 0.11 (0.91) | 0.35 (0.73) |
| Control | 0.59 (0.26) | 0.73 (0.29) | 0.73 (0.44) | 0.78 (0.32) | 0.70 (0.22) | |||||
| CS Stimulus Intensity (% MSO) | ||||||||||
| Patient | 57 (17) | 57 (15) | 53 (13) | 55 (15) | 55 (16) | 0.15 (0.88) | 1.21 (0.24) | 0.65 (0.53) | 0.20 (0.84) | 0.08 (0.94) |
| Control | 58 (8) | 49 (10) | 49 (4) | 56 (14) | 56 (15) | |||||
| TS Stimulus Intensity (% MSO) | ||||||||||
| Patient | 57 (19) | 59 (20) | 60 (16) | 63 (18) | 57 (17) | 0.19 (0.85) | 0.61 (0.55) | 0.79 (0.44) | 0.01 (0.99) | 0.40 (0.69) |
| Control | 59(9) | 54 (7) | 54 (8) | 63 (11) | 60 (12) | |||||
| IHIpremove | CS Stimulus Intensity (% MSO) | |||||||||
| Patient | 56 (17) | 57 (16) | 55 (18) | 58 (16) | 54 (14) | 0 (1.00) | 1.12 (0.28) | 0.70 (0.49) | 0.23 (0.82) | 0.30 (0.77) |
| Control | 56 (8) | 50 (10) | 49 (4) | 56 (14) | 56 (15) | |||||
| TS Stimulus Intensity (% MSO) | ||||||||||
| Patient | 55 (18) | 52 (16) | 60 (19) | 60 (18) | 56 (14) | 0.35 (0.73) | 0.60 (0.55) | 1.12 (0.28) | 0.32 (0.75) | 0.50 (0.62) |
| Control | 52(7) | 48 (6) | 50(6) | 58(9) | 53 (12) | |||||
| MEP Amplitude in Patient (mV) | aCST vs TS | |||||||||
| aCST | 2.89 (1.36) | 3.71 (1.99) | 3.27 (1.80) | 2.78 (1.53) | 3.27 (2.12) | |||||
| TS at 95% RT | 2.22 (1.46) | 2.51 (1.07) | 2.00 (1.28) | 1.68 (1.32) | 1.81 (0.99) | 1.05 (0.31) | 1.91 (0.07) | 2.13 (0.04*) | 2.28 (0.03*) | 2.48 (0.02*) |
| TS at 80% RT | 1.81 (1.06) | 1.82 (0.91) | 1.64 (1.26) | 1.33 (1.23) | 1.55 (0.81) | 1.97 (0.06) | 3.11 (0.005*) | 2.74 (0.01*) | 3.10 (0.004*) | 3.02 (0.005*) |
| Patient | rMT | Paretic vs Nonparetic | ||||||||
| Paretic | 62 (24) | 54 (21) | 50 (13) | 47 (14) | 46 (13) | 3.34 (0.002*) | 2.74 (0.009*) | 2.72 (0.01*) | 1.70 (0.10) | 1.48 (0.15) |
| Non-paretic | 42 (11) | 40 (9) | 40 (9) | 40 (10) | 40 (10) | |||||
| Control | Paretic vs Control | |||||||||
| Dominant | 47(7) | 46 (8) | 48 (9) | 45 (8) | 45(7) | 1.95 (0.06) | 1.20 (0.24) | 0.51 (0.62) | 0.42 (0.68) | 0.25 (0.81) |
| Non-dominant | 43 (9) | 42(7) | 41 (6) | 42(7) | 40 (6) | 2.43 (0.02*) | 1.87 (0.07) | 2.08 (0.046* | 1.19 (0.24) | 1.42 (0.167) |
Reported here are mean and standard deviations (SD) of IHI at rest (IHIrest), CS and TS stimulation intensities for resting and premovement IHI, MEP amplitude in patients for active corticospinal track integrity (aCST) assessed with 100% MSO, TS at 95 and 80% of RT, and resting motor threshold (rMT) in patients and controls. Independent-samples t tests were done between patients and controls for IHIrest and CS and TS intensities at each time point. MEP amplitudes were compared between aCST and TS at each time point among patients. Comparison of rMT were done between paretic versus nonparetic hands in patients, and dominant versus nondominant hands in healthy controls.
TMS = transcranial magnetic stimulation; IHI = interhemispheric inhibition; CS = conditioning stimulus; TS = testing stimulus; RT = reaction time; MSO = maximal stimulator output; MEP = motor-evoked potential
= statistically significant.