Table 7.
Effect of adding different types of coatings to the NPs.
| Author | NPs type and size | Type of added ligant | Treatment | Effect/distribution | Benefit |
|---|---|---|---|---|---|
| Liu et al. [52] | Coated BVP-PLA-NPs 177 and 319 nm | BVP | IV administration | Liver, spleen, heart, brain | NPs penetrate the BBB, avoid the RES, prolong the half-life of BVP |
| Takeuchi et al. [51] | Gold NPs 20, 40 and 80 nm | PEG | IV administration | Usefulness of PEG with smaller NPs size | Reduced accumulation in liver, spleen, improved delivery to the brain |
| Ezealisiji and Okorie [72] | Ag NPs | Peg, PG, Tween, NaLSo4 | Dermatological application (skin penetration) | Maximum penetration efficacy of NaLSo4 followed by PG | Improved skin penetration |
| Hu et al. [125] | PEG-PLA nanoparticles | Peptide F3 PEG-PLA nanoparticles | IV treatment of glioma | Enhanced accumulation at the tumor site and deep penetration into the glioma parenchyma | Improved parenchyma penetration |