Table 1.

Unadjusted associations of patient characteristics with an osteoporosis medication or antiresorptive agent.

Variable	Osteoporosis medication				Antiresorptive agent
	Total (n = 5660)	P-value	Females (n = 4868)	P-value	Total (n = 5660)	P-value	Females (n = 4868)	P-value
Continuous variablea
Age	0.294	<0.0001	0.340	<0.0001	0.266	<0.0001	0.302	<0.0001
Body mass index	−0.100	<0.0001	−0.0582	<0.0001	−0.0797	<0.0001	−0.0485	0.00079
Duration of RA	0.259	<0.0001	0.274	<0.0001	0.199	<0.0001	0.209	<0.0001
DAS28	0.181	<0.0001	0.160	<0.0001	0.150	<0.0001	0.139	<0.0001
JHAQ-DI	0.280	<0.0001	0.271	<0.0001	0.217	<0.0001	0.210	<0.0001
ESR	0.163	<0.0001	0.143	<0.0001	0.141	<0.0001	0.131	<0.0001
CRP	0.0782	<0.0001	0.0976	<0.0001	0.0627	<0.0001	0.0794	<0.0001
MTX dose	−0.0155	0.306	−0.0139	0.394	−0.0211	0.163	−0.0186	0.255
PSL dose	0.278	<0.0001	0.276	<0.0001	0.229	<0.0001	0.225	<0.0001
Categorical variableb
Female sex	3.62	<0.0001	–	–	3.51	<0.0001	–	–
Current smoking	0.606	<0.0001	0.745	0.0261	0.562	<0.0001	0.681	0.0161
Current alcohol	0.568	<0.0001	0.662	<0.0001	0.597	<0.0001	0.674	<0.0001
Self-reported fracture history	1.93	<0.0001	2.12	<0.0001	1.86	<0.0001	1.99	<0.0001
RF positive	1.08	0.2111	1.01	0.841	1.11	0.1779	1.05	0.514
Medication use
MTX	0.967	0.619	0.978	0.777	0.962	0.616	0.998	0.981
bDMARDs	1.01	0.842	0.947	0.448	0.946	0.488	0.897	0.179
Glucocorticoid	3.58	<0.0001	3.58	<0.0001	3.11	<0.0001	2.99	<0.0001
Hypertension	1.98	<0.0001	2.46	<0.0001	1.96	<0.0001	2.33	<0.0001
Hyperlipidemia	1.82	<0.0001	1.92	<0.0001	1.73	<0.0001	1.80	<0.0001
Diabetes mellitus	1.27	0.09122	1.80	0.000247	1.30	0.0469	1.76	0.00138

RA, rheumatoid arthritis; DAS, disease activity score; JHAQ-DI, Japanese Health Assessment Questionnaire-Disability Index; ESR, erythrocyte sedimentation rate; CRP, C-reactive protein; RF, rheumatoid factor; MTX, methotrexate; PSL, prednisolone; bDMARD, biologic disease-modifying antirheumatic drugs.

^aSpearman rank correlation for coefficient continuous variables.

^bOdds ratios from Fisher exact test of categorical variables.