Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jul 15;14:193. doi: 10.3389/fncel.2020.00193

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2020 Yu, Yu, Bu, He and Feng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

FKBP5 aggravated cell damage via autophagy. (A) CCK-8 assay was performed to assess the influences of FKBP5 and autophagy on cell viability. **P < 0.01 vs. control group. ^#P < 0.05 vs. OGD/R + FKBP5(+)-NC group. ^▴P < 0.05 vs. OGD/R + FKBP5(−)-NC group. ^&P < 0.05 vs. OGD/R group. ^▾P < 0.05 vs. OGD/R + 3-MA+FKBP5(+)-NC group. (B–D) Western blot analysis of SQSTM1 and LC3B II expression in FKBP5 stably transfected cell lines. GAPDH was regarded as an endogenous control. Data are presented as the mean ± SD. Statistical analysis was conducted with nonparametric Mann–Whitney test. **P < 0.01 vs. control group. ^#P < 0.05 vs. OGD/R group. (E) TEM was used to observe the autophagosomes in OGD/R cells with altered FKBP5 expression. Arrows point to autophagic vacuoles (AVs) with double membranes. Scale bars represent 1 μm. For (A–E), n = 3 in each group.