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. 2020 Jul 15;14:193. doi: 10.3389/fncel.2020.00193

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Copyright © 2020 Yu, Yu, Bu, He and Feng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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FKBP5-regulated AKT/FOXO3 signaling pathway. (A–C) Protein levels of p-FOXO3/FOXO3 and p-AKT/AKT in the OGD/R group with altered FKBP5 expression. *P < 0.05 vs. control group. ^#P < 0.05 vs. OGD/R + FKBP5(+)-NC group. ^▴P < 0.05 vs. OGD/R + FKBP5(−)-NC group. (D–F) Western blot analysis of p-FOXO3, FOXO3, p-AKT, and AKT expression in OGD/R cells with the treatment of FKBP5(−) and LY294002. GAPDH was regarded as an endogenous control. *P < 0.05 vs. control group. ^#P < 0.05 vs. OGD/R + FKBP5(−)-NC group. ^▴P < 0.05 vs. OGD/R + FKBP5(−) group. For (A–F), n = 3 in each group.