Figure 5. Tissue distribution of pDNA in New Zealand White Rabbits after topical pDNA/PEIm nanoparticle vaccination with DermaPrep.
(a) percentage of pDNA in 10 rabbits per test days (black bars: test day 7, grey bars: test day 30). (b) Average copy numbers of pDNA detected in the lymph nodes on days 7, 30 and 60 (circles and solid line). Calculated elimination rate of the nanoparticles from the lymph nodes (x and dashed line).