Table 3.

Sensitivity, specificity, positive predictive value, and negative predictive values of various FRAX^(R) MOFP and HFP thresholds to identify osteoporosis on DXA.

Variable	Sensitivity (95% CI)	Specificity (95% CI)	PPV (95% CI)	NPV (95% CI)
FRAX® MOFP threshold
≥3.7% (optimal cutoff by Youden index)	0.78 (0.73–0.83)	0.63 (0.59–0.66)	0.4 (0.36–0.44)	0.9 (0.87–0.92)
≥3%	0.84 (0.79–0.89)	0.51 (0.47–0.54)	0.35 (0.32–0.39)	0.91 (0.88–0.94)
≥8%	0.48 (0.42–0.54)	0.89 (0.86–0.91)	0.58 (0.51–0.64)	0.84 (0.82–0.87)
≥10%	0.39 (0.33–0.46)	0.94 (0.92–0.95)	0.67 (0.59–0.74)	0.83 (0.8–0.85)
≥15%	0.3 (0.24–0.36)	0.99 (0.98–0.99)	0.87 (0.78–0.93)	0.81 (0.79–0.84)
FRAX® HFP threshold
≥0.6% (optimal cutoff by Youden index)	0.85 (0.8–0.89)	0.58 (0.55–0.62)	0.39 (0.35–0.43)	0.92 (0.9–0.94)
≥0.5%	0.89 (0.84–0.93)	0.46 (0.43–0.5)	0.34 (0.31–0.38)	0.93 (0.9–0.95)
≥1%	0.75 (0.69–0.8)	0.68 (0.64–0.71)	0.42 (0.38–0.47)	0.89 (0.87–0.92)
≥2%	0.54 (0.47–0.6)	0.85 (0.83–0.88)	0.54 (0.48–0.6)	0.85 (0.83–0.88)
≥3%	0.45 (0.39–0.51)	0.92 (0.9–0.94)	0.63 (0.56–0.7)	0.84 (0.81–0.86)

MOFP, Major Osteoporotic Fracture Probability; HFP, Hip Fracture Probability; DXA, dual energy X-ray absorptiometry; CI, confidence interval; PPV, positive predictive value; NPV, negative predictive value.