Table 4.

Sensitivity, specificity, positive predictive value, and negative predictive value for FRAX® MOFP and FRAX® HFP thresholds of 6.3% and 1.63% (i.e., FRAX® probabilities equivalent to that of a 65-year-old Singaporean woman of average BMI and no clinical risk factors) to identify osteoporosis on DXA scan in women <65 years old.

Threshold	Sensitivity (95% CI)	Specificity (95% CI)	PPV (95% CI)	NPV (95% CI)
FRAX® MOFP score ≥ 6.3%	0.17 (0.11–0.24)	0.95 (0.93,0.96)	0.39 (0.26–0.52)	0.85 (0.83–0.88)
FRAX® HFP score ≥ 1.63%	0.19 (0.12–0.28)	0.95 (0.93–0.96)	0.33 (0.21–0.47)	0.89 (0.87–0.91)

MOFP, Major Osteoporotic Fracture Probability; HFP, Hip Fracture Probability; BMI, body mass index; DXA, dual energy X-ray absorptiometry; CI, confidence interval; PPV, positive predictive value; NPV, negative predictive value.