Table 4.

Reasons for Being Willing or Unwilling to Consider Participating

Respondents who were willing (all questions combined) (n = 1658)
Reason	n (%)*
Benefit to others	934 (56.3)
Clinical benefit to the participant	317 (19.1)
Safe	159 (9.6)
Drug similarity	156 (9.4)
Trust in a specific physician or institution	130 (7.8)
Favorable view of randomization	127 (7.7)
Ability to switch medications	112 (6.8)
Conditional on transparency and information	68 (4.1)
Conditional on a patient’s ability to make an active choice	33 (2.0)
Misconceptions about ROMP	30 (1.8)
No added risk beyond usual care	28 (1.7)
General or institutional trust or mistrust	21 (1.3)
Curiosity	17 (1.0)
Respondents who were unwilling (all questions combined) (n = 505)
Reason	n (%)*
Unsafe	178 (35.2)
Unfavorable view of experimentation	136 (27.0)
Desire for physician control over treatment decisions	60 (11.9)
Unfavorable view of randomization	37 (7.3)
Conditional on a patient’s ability to make an active choice	34 (6.7)
Conditional on transparency and information	34 (6.7)
Misconceptions about ROMP	30 (6.0)
Privacy or confidentiality	24 (4.8)
General or institutional trust or mistrust	21 (4.2)
Doubt in drug similarity	8 (1.6)

^*All relevant codes were applied to each response, so percentages do not sum to 100%.