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. 2020 Jul 21;10:12063. doi: 10.1038/s41598-020-67699-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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SNP-based results of ADNI-2. (A) The classification performance of SNP based analyses performed in ADNI-2 considering two classification tasks: AD vs. healthy controls (cases@controls) or 1/2 APOEe4 vs. 0 APOEe4 carriers (APOEe4 task). B. ACC, Balanced Accuracy; MCC, Matthews Correlation Coefficient; #genes*, number of genes or intergenic regions. (B) Balanced accuracy distribution plots of regular (light blue) and permutation (red) batches related to chromosomes 9, 10, 14, 20, 21 in the cases@controls task. (C) Balanced accuracy distribution plots of regular (light blue) and permutation (red) batches related to chromosome 19 in the APOEe4 task.