Table 3.
Functional characterization in KEGG.
| Functional characterization | ||||
|---|---|---|---|---|
| KEGG database | ||||
| Pathway name | #Genes | Adj-P-value | Gene symbol | |
| ADNI-1 | Neuroactive ligand-receptor interaction | 5 | 5.99e-06 | P2RY13, GRIN3A, LEPR, GRM7, P2RY14 |
| Pathway name | #Genes | Adj-P-value | Gene Symbol | |
| ADNI-2 | Calcium signaling pathway | 4 | 0.0040 | PLCB4, GRIN2A, CYSLTR2, ADCY9 |
| Neuroactive ligand-receptor interaction | 4 | 0.0064 | GRM7, GRIN2A, CYSLTR2, GABRG3 | |
| Axon guidance | 3 | 0.0064 | ABL1, EPHA6, NTN1 | |
| Chemokine signaling pathway | 5 | 0.0080 | PLCB4, GNG2, JAK2, NFKB1, ADCY9 | |
Pathways enrichment results of the SNPs signatures identified in ADNI-1 and ADNI-2 dataset, considering the APOEe4 and cases@controls tasks respectively. #genes*, number of genes Adj-P-value, adjusted P-value.
The pathways names highlighted in bold are commented in the main text.