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. 2020 Jul 21;10:12049. doi: 10.1038/s41598-020-67956-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Hierarchical clustering of the COMET IPF patients by the LASSO-identified blood and BAL protein signature highlights a single group of non-progressors (purple) and three groups of progressors (cyan) with distinct expression levels of various proteins in the signature. Only 5 out of the 50 patients were misclassified. Protein expression level is shown in the color scale on the left of the figure, with red indicating higher concentration compared to the mean, and blue lower concentration compared to the mean.