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. 2020 Jul 21;10:12055. doi: 10.1038/s41598-020-68881-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The variance accounted for by predictor SNPs which are both in genic regions and detected by the UK Biobank exome data, as a percentage of the total variance accounted for by all predictor SNPs, for each disease condition. The disease conditions are listed from left to right on the horizontal axis in order of decreasing percentage. Each vertical bar is colored blue with a depth of shade proportional to the height of the bar. Here, “genic” SNPs are contained within the GENCODE Release 19 gene boundaries plus 30 kilo base pairs at both ends.