Table 4.
Criterion values and coordinates of the ROC curve of serum IL-32 concentration for distinguishing COPD from healthy people.
| Criterion | Sensitivity | 95% CI | Specificity | 95% CI | + LR | 95% CI | − LR | 95% CI |
|---|---|---|---|---|---|---|---|---|
| > 53 | 100.00 | 96.9–100.0 | 12.86 | 6.1–23.0 | 1.15 | 0.6–2.1 | 0.00 | – |
| > 63 | 99.14 | 95.3–100.0 | 15.71 | 8.1–26.4 | 1.18 | 0.7–2.0 | 0.055 | 0.008–0.4 |
| > 87 | 96.55 | 91.4–99.1 | 37.14 | 25.9–49.5 | 1.54 | 1.1–2.1 | 0.093 | 0.03–0.2 |
| > 90 | 89.66 | 82.6–94.5 | 41.43 | 29.8–53.8 | 1.53 | 1.2–2.0 | 0.25 | 0.1–0.4 |
| > 94 | 88.79 | 81.6–93.9 | 48.57 | 36.4–60.8 | 1.73 | 1.3–2.2 | 0.23 | 0.1–0.4 |
| > 101 | 87.93 | 80.6–93.2 | 58.57 | 46.2–70.2 | 2.12 | 1.7–2.6 | 0.21 | 0.1–0.4 |
| > 105* | 85.34 | 77.6–91.2 | 64.29 | 51.9–75.4 | 2.39 | 2.0–2.9 | 0.23 | 0.1–0.4 |
| > 113 | 70.69 | 61.5–78.8 | 70.00 | 57.9–80.4 | 2.36 | 1.9–2.9 | 0.42 | 0.3–0.7 |
| > 123 | 60.34 | 50.8–69.3 | 71.43 | 59.4–81.6 | 2.11 | 1.7–2.6 | 0.56 | 0.4–0.9 |
| > 139 | 56.90 | 47.4–66.1 | 84.29 | 73.6–91.9 | 3.62 | 3.0–4.4 | 0.51 | 0.3–0.9 |
| > 150 | 47.41 | 38.1–56.9 | 90.00 | 80.5–95.9 | 4.74 | 3.9–5.8 | 0.58 | 0.3–1.2 |
| > 163 | 42.24 | 33.1–51.8 | 97.14 | 90.1–99.7 | 14.78 | 11.9–18.4 | 0.59 | 0.2–2.4 |
| > 181 | 37.07 | 28.3–46.5 | 100.00 | 94.9–100.0 | – | – | 0.63 | – |
ROC receiver operating characteristic curve, IL-32 interleukin-32, COPD chronic obstructive pulmonary disease, 95% CI 95% confidence, +LR positive likelihood ratio, −LR negative likelihood ratio.