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. 2020 May 18;123(2):196–206. doi: 10.1038/s41416-020-0881-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Box and whisker plots of intratumoural and peritumoural counts/mm² stratified by histopathological growth pattern (HGP) and displayed on a logarithmic scale. The white line represents the median, the box represents the interquartile range (IQR), and the whisker represents the range. Outliers are defined according to the 1.5 rule (i.e. outside [Q1 − 1.5 × IQR; Q3 + 1.5 × IQR]). b Linear regression models of intratumoural and peritumoural counts/mm² (y-axis, logarithmic scale) and the percentage of the desmoplastic-type histopathological growth pattern (dHGP) scored at the tumour–liver interface (x-axis). The blue line represents the regression coefficient; the light blue ribbon represents the corresponding 95% confidence interval. Measurements of individual patients are displayed using dots. Red dots represent patients with non-dHGP (i.e. <100% dHGP), and blue dots represent patients with dHGP (i.e. 100% dHGP).