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. 2020 May 11;123(2):226–239. doi: 10.1038/s41416-020-0877-8

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© The Author(s), under exclusive licence to Cancer Research UK 2020

Note This work is published under the standard license to publish agreement. After 12 months the work will become freely available and the license terms will switch to a Creative Commons Attribution 4.0 International (CC BY 4.0).

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Fig. 3 — J82 and J82-Ras cells were treated with Rom+Cis+Gem at their IC₁₀ doses for J82-Ras cells for 48 h to induce differential cell death. a Heatmap of 179 differentially expressed genes (>2-fold change, FDR < 0.05), induced by Rom+Cis+Gem, that are functionally associated with ROS, cell death, or drug resistance. Colour code represents the z-score of the expression. b Venn diagram of differentially regulated genes, induced by Rom+Cis+Gem, functionally associated with ROS, cell death, drug resistance, DNA repair, autophagy, or drug transport in J82 and J82-Ras cells were compared. c Quantification of upregulated ROS-, cell death-, and drug resistance-associated gene expression levels. Upper panel shows the folds of increases. Lower panel shows the associated p values. Fisher’s exact test was used to obtain statistical significance: *p < 0.05, **p < 0.01, not significant (NS) p > 0.05.

Fig. 3 — J82 and J82-Ras cells were treated with Rom+Cis+Gem at their IC₁₀ doses for J82-Ras cells for 48 h to induce differential cell death. a Heatmap of 179 differentially expressed genes (>2-fold change, FDR < 0.05), induced by Rom+Cis+Gem, that are functionally associated with ROS, cell death, or drug resistance. Colour code represents the z-score of the expression. b Venn diagram of differentially regulated genes, induced by Rom+Cis+Gem, functionally associated with ROS, cell death, drug resistance, DNA repair, autophagy, or drug transport in J82 and J82-Ras cells were compared. c Quantification of upregulated ROS-, cell death-, and drug resistance-associated gene expression levels. Upper panel shows the folds of increases. Lower panel shows the associated p values. Fisher’s exact test was used to obtain statistical significance: *p < 0.05, **p < 0.01, not significant (NS) p > 0.05.