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. 2020 May 11;123(2):275–287. doi: 10.1038/s41416-020-0865-z

Fig. 3. PDK4 is overexpressed in ovarian cancer and correlates with metastasis and poor prognosis.

Fig. 3

a Representative images (scale bar, 100 μΜ) of IHC staining for PDK4 expression in (i) normal ovarian tissue, (ii) serous, (iii) mucinous, (iv) endometrioid and (v) clear cell subtypes of tumour samples on ovarian cancer TMA (OVC1021, Biomax). b Correlation of PDK4 with clinicopathologic parameters in ovarian cancer. c (Left) Overall and (right) progression-free survival rates were analysed with the log-rank test for PDKhigh/low groups of ovarian cancer patients obtained from TGCA using the Kaplan–Meier plotter. d (Left) Representative images (scale bar, 100 μΜ) of IHC staining for PDK4 expression in ovarian primary and matched metastatic tumours. (Right) Dot plot showing PDK4 positivity in primary and metastatic ovarian tumours. e PDK4 mRNA expression in normal human ovarian surface epithelial cell line (HOSE) and ovarian cancer cell lines as determined by qPCR (*p < 0.05, **p < 0.01; n.s., not significant).