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. 2020 Jul 21;11:3654. doi: 10.1038/s41467-020-17474-0

Table 2.

The results of Knoevenagel reactions between various rhodanine with aldehyde compounds.

Entry Rhodaninea Aldehydeb Solvent Time (h) Conversion (%)c
1 1b 3a DMSO 0.5 99
2 1b 3b DMSO 0.5 99
3 1b 3c DMSO 1.5 99
4 1b 3d DMSO 0.5 98
5 1b 3e DMSO 0.5 99
6 1c 3a DMSO 1.5 98
7 1b 3a MECN 0.75 98
8 1b 3a DMF 0.5 99

The reactions were performed at 70 °C, [rhodanine] = [aldehyde] = 0.4 M, [TEA] = 0.1 M.

aVarious rhodanine compounds in Fig. 4a.

bVarious aldehyde compounds in Fig. 4a.

cDetermined by 1H NMR.