Table 3.
Cox proportional hazard regression model for overall survival.
| Parameter | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | |
| Age (≥ 63) | 1.31 (0.75–2.29) | 0.341 | ||
| Smoking history | 0.85 (0.47–1.55) | 0.601 | ||
| Alcohol history | 1.00 (0.57–1.76) | 0.989 | ||
| CCI (≥ 3 points) | 0.58 (0.00–134.19) | 0.453 | ||
| AJCC pT (T3, T4a and T4b) | 1.74 (0.10–3.05) | 0.051 | ||
| AJCC pN (N2, N3) | 2.35 (1.34–4.11) | < 0.001* | 2.29 (1.27–4.10) | 0.006* |
| Perineural invasion | 2.89 (1.47–5.66) | 0.002* | 2.17 (1.09–4.33) | 0.028* |
| Lymphovascular permeation | 1.78 (0.89–3.57) | 0.102 | ||
| Resection margin status (close or involved) | 0.88 (0.49–1.58) | 0.676 | ||
| NLR (≥ 2.23) | 2.01 (1.15–3.53) | 0.015* | 1.78 (1.01–3.14) | 0.045* |
| LMR (< 4.65) | 0.88 (0.50–1.53) | 0.638 | ||
| PLR (≥ 135.14) | 1.67 (0.96–2.92) | 0.071 | ||
| Albumin (< 4.35) | 1.31 (0.75–2.29) | 0.340 | ||
HR hazard ratio, CI confidence interval, CCI Charlson comorbidity index, AJCC American Joint Committee on Cancer, pT pathologic primary tumor categories, pN pathologic regional lymph node categories, NLR neutrophil–lymphocyte ratio, LMR lymphocyte-monocyte ratio, PLR platelet-lymphocyte ratio.
* Statistically significant.